Two deputies were in a marked radio car when they encountered a man standing on a sidewalk in the 400 block of Wilmington Avenue around 8:30 p.m.
Deputies tried to talk to the man, but he suddenly pulled out a handgun and ran northbound on Wilmington, authorities said. The deputies chased the suspect on foot, eventually catching up to him near the wash on West Arbutus Street, east of North Kemp Avenue.
The suspect pointed the gun at deputies and a deputy-involved shooting occurred, according to authorities. The man was struck by gunfire and pronounced dead at the scene.
Authorities searched for the weapon in the wash and surrounding area. No deputies were injured in the shooting.
The investigation was ongoing.
Anyone with more information was urged to call the L.A. County Sheriff's Department's Homicide Bureau at (323) 890-5500. Those wishing to remain anonymous may call Crime Stoppers at (800) 222-8477.